I am mid-migration, in a co-existence setup with Exchange 2010, 2007 and 2003. So far the roles installed for Exchange 2010 are CAS, Hub and Mailbox on a single server. Into this mix I need to introduce an Edge Server, with message hygiene in the form of Forefront Protection for Exchange (FPE) and Threat Management Gateway (TMG) as a reverse proxy to publish OWA, ActiveSync et-al.
Since Edge, FPE and TMG can now all exist on a single 64-bit server, I will start with a clean installation of Windows Server 2008 R2, up to date with all the latest hot fixes.