If you are close to the VMware ESXi storage path limit of 1024 paths per host, you may want to consider the following: local storage, including CD-ROMs, are counted in your total paths.
Simply because of the size and age of the environment, some of our production clusters have now reached the limit (including local paths) - you see this message in the logs
[2012-08-20 01:48:52.256 77C3DB90 info ‘ha-eventmgr’] Event 2003 : The maximum number of supported paths of 1024 has been reached.